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Similarly, while Sativex and smoked cannabis have not been employed in the same clinical trial, comparisons of side effect profiles can be made on the basis of SAFEX studies of Sativex for over a year and up to several years in MS and other types of neuropathic pain (Russo 2006b; Wade et al 2006), and government-approved research programs employing standardized herbal cannabis from Canada for chronic pain (Lynch et al 2006) and the Netherlands for general conditions (Janse et al 2004; Gorter et al 2005) over a period of several months or more.
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When a person smokes marijuana all of the various chemicals in the plant are inhaled, ultimately, into the brain where they find and bind to these receptors similar to a key fitting into a lock.
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While the Selective Reminding Test did not change significantly on Sativex, placebo patients displayed unexpected improvement.
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